Polymorphisms of ATP-Binding Cassette, Sub-Family A, Member 4 (rs560426 and rs481931) and Non-Syndromic Cleft Lip/Palate: A Meta-Analysis

Background: A number of genes are associated with the incidence non-syndromic cleft lip/palate (NSCL/P). Studies have shown a significant association between polymorphisms ATP-binding cassette, sub-family A, member 4 (ABCA4) risk NSCL/P. The present meta-analysis assessed ABCA4 (rs560426 and rs481931) NSCL/P by reviewing case-control studies. Methods: Four databases (Scopus; Cochrane Library; Web Science; PubMed) were searched for articles published up to June 2020. Review Manager 5.3 software was used calculate crude odds ratio (OR) 95% confidence interval (CI). Both subgroup analyses ethnicity source controls meta-regression related publication year conducted. Results: Of 94 retrieved studies, 12 analyzed in this (2859 patients 3792 rs560426 polymorphism 1333 1884 rs481931 polymorphism). Overall, there no both However, analysis demonstrated that higher specific models: allelic model (OR = 1.13; p 0.03), homozygote 1.53; 0.04), recessive 1.30; 0.03) Asian polymorphism. Conclusion: findings confirmed significantly G allele GG genotype but not There associations those European descent mixed ethnicities.